Former pharma CDMO process development chemist. I had the molecule from hell.
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Prompt: Former pharma CDMO process development chemist. I had the molecule from hell that 2 previous labs failed to isolate as anything other than an oil. Highly polar regions on the ends of 3 separate long C18 chains around a fused heterocycle core. With some screening to find some anti-solvent conditions that would cause the oil to turn to a waxy/gummy solid. One day on a lark I set up the weirdest seed crystal generation experiment - RBF in a sonicator, dose the antisolvent and I got 'crystal-ish' solids (probably just crystals coated in waxy oil). It then took another few days of screening to find a ternary solvent system that would use those seed crystals to generate proper crystals in bulk (thank you Ostwald ripening!) that would dry nicely under just a nitrogen flow to meet ICH Q7 residual solvent specs.
So yeah, polymorphs and crystallization can just get downright weird. Didn't have an XRD back then, and the molecule failed in the clinic.
Dream Level: is increased each time when you "Go Deeper" into the dream. Each new level is harder to achieve and
takes more iterations than the one before.
Rare Deep Dream: is any dream which went deeper than level 6.
Deep Dream
You cannot go deeper into someone else's dream. You must create your own.
Deep Dream
Currently going deeper is available only for Deep Dreams.
